VCAM-1, but Not ICAM-1 or MAdCAM-1, Immunoblockade Ameliorates DSS-Induced Colitis in Mice
نویسندگان
چکیده
منابع مشابه
A major role for VCAM-1, but not ICAM-1, in early atherosclerosis.
VCAM-1 and ICAM-1 are endothelial adhesion molecules of the Ig gene superfamily that may participate in atherogenesis by promoting monocyte accumulation in the arterial intima. Both are expressed in regions predisposed to atherosclerosis and at the periphery of established lesions, while ICAM-1 is also expressed more broadly. To evaluate functions of VCAM-1 in chronic disease, we disrupted its ...
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Objective: Many diabetic patients are susceptible to cardiovascular diseases which are known as one of the most important causes of mortality among diabetic patients. The aim of this study was to investigate the effects of eight weeks of resistance training on VCAM-1, ICAM-1 and CRP in diabetic rats. Materials and Methods: In this experimental study, 24 male Sprague- Dawley diabetic rats were ...
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The anti-inflammatory effect and potential mechanism of cardamonin in 1 DSS-induced colitis 2 3 Gaiyan Ren, Aning Sun, Chao Deng, Jingjing Zhang, Xiaojun Wu, Xiaohui 4 Wei1, Sridhar Mani2, Wei Dou1 and Zhengtao Wang1 5 6 1 Shanghai Key Laboratory of Complex Prescription and MOE Key Laboratory for 7 Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai 8 University ...
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The induction and perpetuation of chronic colitis are thought to involve a complex set of adhesive interactions between T cells and endothelial cells located on the vasculature within secondary lymphoid tissue and the intestine. The objective of this study was to assess the roles of T cell-associated CD18, CD62L (L-selectin), ICAM-1, and P-selectin glycoprotein ligand-1 (PSGL-1) in the inductio...
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Soluble vascular cell adhesion molecule (sVCAM-1) and soluble intercellular adhesion molecule (sICAM-1) are adhesion molecules that are detectable in the serum of patients with cancer, cardiovascular diseases (CVD), and type 2 diabetes. This report describes enzyme-linked immunosorbent assays (ELISAs) on microplates for sVCAM-1 and sICAM-1. The ELISAs have the sandwich test format; polyclonal a...
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ژورنال
عنوان ژورنال: Laboratory Investigation
سال: 2000
ISSN: 0023-6837,1530-0307
DOI: 10.1038/labinvest.3780164